CD10-MUM1+ follicular
lymphoma lacks BCL2 gene translocation and
shows characteristic biologic and clinical
features.
Karube K, Guo Y,
Suzumiya J, Sugita Y,
Nomura Y, Yamamoto K,
Shimizu K, Yoshida S,
Komatani H, Takeshita M,
Kikuchi M, Nakamura N,
Takasu O, Arakawa F,
Tagawa H, Seto M, Ohshima
K.
Department of
Pathology, State Key Laboratory of Cancer
Biology, Xijing Hospital, Fourth Military
Medical University, Xi'an, Shannxi, People's
Republic of China. karube1975@yahoo.co.jp
CD10 and MUM1 are
representative B cell differentiation
markers. Follicular lymphoma (FL) is usually
positive for CD10 and negative for MUM1. In
this study, however, we compared 22 FLs with
peculiar phenotype CD10-MUM1+ with 119
typical CD10+MUM1- FLs. All CD10-MUM1+ FL
patients exhibited follicular structure with
follicular dendritic meshwork, and a high
rate of somatic hypermutation and ongoing
mutation, similar to typical FL. However,
CD10-MUM1+ FLs were encountered frequently
in the elderly compared with CD10+MUM1-
typical FLs (67.0 versus 58.7 years, P <
.01), showed high grade (grade 3A or 3B)
morphology (91% versus 17%, P < .001),
diffuse proliferation (59% vs 19%, P <
.001), and lacked BCL2/IGH translocation (5%
versus 92.5%, P < .001), which is the most
characteristic aberration in FL, and 88%
showed BCL6 gene abnormalities
(translocation or amplification). Our
results indicate that CD10-MUM1+ FL is
different from typical FL with respect to
biologic and clinical features.
PMID: 17138820 [PubMed -
indexed for MEDLINE]