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Blood.
2006 Dec 15;108(13):4194-7. Epub 2006 Aug 31.
CD200 is a new prognostic factor in
multiple myeloma.
Moreaux J,
Hose D, Reme T, Jourdan E, Hundemer M, Legouffe E,
Moine P, Bourin P, Moos M, Corre J, Mohler T, De Vos
J, Rossi JF, Goldschmidt H, Klein B.
Centre Hospitalier Universitaire (CHU) Montpellier,
Department of Hematology and Clinical Oncology and
Institute of Research in Biotherapy, Montpellier,
France.
Using Affymetrix microarrays, we
identified the expression of the CD200 gene in
multiple myeloma cells (MMCs) of 112 patients with
newly diagnosed multiple myeloma (MM). The CD200
gene was either absent or present (Affymetrix call)
in 22% and 78% of MMCs, respectively. The CD200 gene
is not expressed in cells of the patients' bone
marrow (BM). CD200 is a membrane glycoprotein that
imparts an immunoregulatory signal through CD200R,
leading to the suppression of T-cell-mediated immune
responses. Patients with CD200(absent) MMCs have an
increased event-free survival (EFS; 24 months)
compared with patients with CD200(present) MMCs (14
months), after high-dose therapy and stem cell
transplantation. In a Cox proportional-hazard model,
the absence or presence of CD200 expression in MMCs
is predictive for EFS for patients independently of
ISS stage or beta2M serum levels. Thus, CD200 is an
independent prognosis factor for patients with MM
that could represent a new therapeutic target in MM.
PMID: 16946299 [PubMed - indexed for
MEDLINE]