-
Am J Clin Pathol. 1996 Jan;105(1):31-7.-
Comment in:
- Am J Clin Pathol. 1996 Sep;106(3):438.
CD5+ extranodal marginal zone
B-cell (MALT) lymphoma. A low grade neoplasm with a
propensity for bone marrow involvement and relapse.
Ferry
JA,
Yang WI, Zukerberg LR, Wotherspoon AC, Arnold A,
Harris NL.
James Homer Wright Pathology Laboratories,
Massachusetts General Hospital, Boston 02114, USA.
Three cases of extranodal
marginal zone B-cell lymphoma (low grade B-cell
lymphoma of mucosa-associated lymphoid tissue [MALT]
type) in which the neoplastic B cells expressed the
CD5 antigen are reported. The patients included 2
men and 1 woman, aged 44, 62, and 77 years. In all
three cases, the histologic features were typical of
marginal zone/MALT lymphoma, with reactive
follicles, marginal zone (centrocyte-like) cells,
and plasma cells. Pseudofollicles, prolymphocytes,
and paraimmunoblasts were absent. In all cases,
lymphoma from one or more sites expressed monotypic
immunoglobulin (2 IgM kappa, 1 IgM lambda), pan B
cell antigens and CD5. Two of 3 cases expressed
CD43; one case expressed CD23. No case showed
overexpression of the bcl-1 protein, cyclin D1.
Interphase cytogenetic analysis revealed trisomy 3
in one of two cases examined. The two male patients
presented with lymphoma in the ocular adnexa. One of
them had marrow involvement, cervical
lymphadenopathy and peripheral blood involvement at
presentation; 24 months later, he developed a
relapse in subcutaneous tissue. The second patient
had marrow involvement 3 years later, at the time of
recurrence of his orbital disease. The third patient
presented with lymphoma at the base of the tongue.
She subsequently developed lymphoma involving the
left upper eyelid and right lacrimal sac and duct,
the marrow, and the nasopharynx between 63 and 95
months after initial presentation. All of these
patients presented with disease involving sites in
the head and neck and all had multiple relapses or
recurrences with bone marrow involvement at the time
of presentation (1 case) or at relapse (2 cases).
The presence of CD5 may be a marker for cases of
MALT lymphoma with a tendency for persistent or
recurrent disease, for dissemination to the marrow
and other extranodal sites, and for leukemic
involvement of the peripheral blood.
PMID: 8561085 [PubMed - indexed for
MEDLINE]