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- Am J
Clin Pathol. 2005 Oct;124(4):560-8.
Delineation of patterns of bone marrow mast
cell infiltration in systemic mastocytosis: value of CD25,
correlation with subvariants of the disease, and separation from
mast cell hyperplasia.
Krokowski M, Sotlar K, Krauth MT, Fodinger M, Valent P, Horny
HP.
Institute of Pathology, University of Lubeck, Lubeck, Germany.
In most cases, the diagnosis of systemic mastocytosis (SM) is
based on histomorphologic evaluation of the bone marrow. We
analyzed mast cell (MC) infiltration patterns in 57 cases of SM
and 31 cases of mast cell hyperplasia (MCH). Tryptase
immunohistochemical analysis was used for MC detection and CD25
to distinguish neoplastic from normal MCs. The following
infiltration patterns were found: I, diffuse interstitial; II,
focal, dense; III, focal, dense with an additional diffuse
component, located preferentially around focal infiltrates; IV,
focal, dense with an additional diffuse component evenly
distributed throughout; and V, diffuse, dense. In 29 cases of
MCH, MCs formed the type I pattern. The majority of SM cases
exhibited patterns II to V; type IV was the most frequent (n =
36). Type V was seen in 3 cases of MC leukemia and 1 case of
smoldering SM. In 1 case of SM, type I infiltration was found;
the SM diagnosis was based on 3 minor SM criteria. Our data show
that the infiltration pattern in SM correlates with the disease
subtype and should be recognized as an important aspect in the
histomorphologic evaluation of the bone marrow.
PMID: 16146815 [PubMed - indexed for MEDLINE]
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