-
Am J
Pathol. 2001 May;158(5):1593-8.
Differential expression of cytotoxic
molecules and killer cell inhibitory receptors in
CD8+ and CD56+ cutaneous lymphomas.
Kamarashev J, Burg G, Mingari MC, Kempf W,
Hofbauer G, Dummer R.
Department of Dermatology, University Hospital,
Zurich, Switzerland.
Cutaneous lymphomas of the
cytotoxic phenotype, including CD8+ and CD56+
lymphomas, have only recently been recognized. To
characterize the phenotypic profile of these
lymphomas, we investigated the expression of both
cytotoxic molecules and killer cell inhibitory
receptors by immunohistochemistry techniques. Frozen
sections from four CD8+ and from three CD56+
cutaneous lymphomas were stained for the
cytotoxicity markers including T-cell restricted
intracellular antigen-1, perforin, granzyme B, and
for expression of the inhibitory receptors including
p58.1, p58.2, p70, p140, CD94, NKG2, and leukocyte
immunoglobulin-like receptor (LIR-1). Apart from
LIR-1, the CD8+ lymphomas in our series express p70
and p140 from the inhibitory receptors and only one
or two of the cytotoxic proteins. The CD56+
lymphomas, on the other hand, express only LIR-1 of
the set of inhibitory receptors and the whole panel
of cytotoxic antigens. Various subtypes of cytotoxic
cutaneous lymphomas (CD8+ and CD56+) differ in
regard to their phenotypic and functional profile,
which may explain differences in their biological
behavior.
PMID: 11337356 [PubMed - indexed for
MEDLINE]