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J Korean Med Sci. 2005
Dec;20(6):952-6.
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Immunoreactivity of CD99 in
non-Hodgkin's lymphoma: unexpected frequent
expression in ALK-positive anaplastic large
cell lymphoma.
Sung CO, Ko YH, Park S, Kim K, Kim W.
Department of
Pathology, Samsung Medical Center,
Sungkyunkwan University School of Medicine,
Seoul, Korea.
To verify the spectrum
of CD99-expressing lymphoid malignancy, an
immunohistochemical study for CD99 was
carried out in 182 cases of non-Hodgkin's
lymphoma, including 21 lymphoblastic
lymphomas, 11 small lymphocytic lymphomas, 9
mantle cell lymphomas, 12 follicular
lymphomas, 37 diffuse large B cell
lymphomas, 18 Burkitt's lymphomas, 28 NK/T-cell
lymphomas, 8 angioimmunoblastic T-cell
lymphomas, 23 peripheral T-cell lymphomas,
unspecified, and 15 systemic anaplastic
large cell lymphomas. CD99 was positive in
all T-lymphoblastic lymphomas and in 60% of
B-lymphoblastic lymphomas. Majority of T and
NK cell lymphomas were negative for CD99,
except anaplastic large cell lymphomas (ALCLs).
Eight of 15 cases (54%) of ALCLs reacted
with anti CD99 antibody. Seven of 10 (70%)
ALK positive ALCLs expressed CD99, whereas
only 1 of 5 (20%) ALK negative ALCLs were
positive. Of the mature B-cell lymphomas,
5.4% (2/37) of diffuse large B cell
lymphomas and 11.1% (2/18) of Burkitt's
lymphomas expressed CD99. In conclusion,
CD99 is infrequently expressed in mature B
and T cell lymphomas, except ALK-positive
ALCL. High expression of CD99 in ALK-positive
ALCL is unexpected finding and its biologic
and clinical significances have yet to be
clarified.
PMID: 16361803 [PubMed -
indexed for MEDLINE]