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Mod Pathol. 2002 Dec;15(12):1266-72.
Mantle cell lymphoma with 8q24
chromosomal abnormalities: a report of 5 cases with
blastoid features.
Hao S,
Sanger W, Onciu M, Lai R, Schlette EJ, Medeiros LJ.
Department of Hematopathology, The University of
Texas M.D. Anderson Cancer Center, Houston, Texas
77030, USA.
The t(11;14)(q13;q32) resulting
in cyclin D1 overexpression is consistently present
in mantle cell lymphoma. However secondary
chromosomal aberrations are also extremely common.
Of these, 8q24 abnormalities associated with the
t(11;14) are rare. Over the course of 10 years at
M.D. Anderson Cancer Center, we identified five
cases of mantle cell lymphoma in which conventional
cytogenetic analysis revealed complex karyotypes,
including the t(11;14) and 8q24 abnormalities: one
with t(8;14)(q24;q32), one with t(2;8)(q13;q24), and
three with add(8)(q24). We performed fluorescence in
situ hybridization (FISH) studies on all cases. In
the case with the t(8;14), IgH/myc fusion signals
were identified, and in the case with the t(2;8),
split c-myc signals were detected. In the three
cases with add(8)(q24), one case had split c-myc
signals and two cases had three copies of c-myc.
Thus, the c-myc gene was involved in all cases. All
five neoplasms had blastoid morphologic features,
and four cases, including the cases with the t(8;14)
and t(2;8), had leukemic involvement. We conclude
that 8q24 abnormalities involving the c-myc gene are
uncommon secondary abnormalities that occur in a
subset of mantle cell lymphomas. C-myc gene
abnormalities are associated with blastoid cytologic
features and also may be associated with leukemic
involvement.
PMID: 12481006 [PubMed - indexed for
MEDLINE]