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Am J Clin Pathol. 2004 Jul;122(1):122-7.
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An unusual case of leukemic
mantle cell lymphoma with a blastoid component
showing loss of CD5 and aberrant expression of CD10.
Morice
WG,
Hodnefield JM, Kurtin PJ, Hanson CA.
Department of Laboratory Medicine and Pathology,
Mayo Clinic, Rochester, MN 55905, USA.
Characteristically, mantle cell
lymphoma (MCL) expresses surface immunoglobulin (sIg),
CD19, CD20, and CD5 and lacks CD10 and CD23. Rare
CD5-MCL variants have been described. This report
describes a case of leukemic MCL with
morphologically and immunophenotypically distinct
classic MCL and blastoid-variant MCL (BV-MCL)
components. The classic MCL had typical morphologic
features and immunophenotype (kappa sIg light
chain-restricted and CD5+; CD10- and CD23-). The BV-MCL
had larger nuclei and open chromatin; these cells
also were kappa sIg light chain-restricted; however,
they were CD10+ and CD5-. Fluorescence in situ
hybridization studies demonstrated cyclin
D1-immunoglobulin heavy chain gene fusion in both
components; the bone marrow biopsy cellularity was
replaced by CD10+ and cyclin D1+ and CD5-BV-MCL.
This case illustrates the phenotypic heterogeneity
of MCL and underscores the need for histopathologic
correlation and, in some instances, ancillary
genetic studies to accurately classify B-cell
lymphomas.
PMID: 15272540 [PubMed - indexed for
MEDLINE]