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Am J Clin Pathol. 2001 Dec;116(6):886-92.
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Cytogenetic findings in mantle
cell lymphoma cases with a high level of peripheral
blood involvement have a distinct pattern of
abnormalities.
Onciu
M,
Schlette E, Medeiros LJ, Abruzzo LV, Keating M, Lai
R.
Department of Hematopathology, University of Texas
M.D. Anderson Cancer Center, Houston 77030, USA.
We compared conventional
cytogenetic findings in mantle cell lymphomas (MCLs)
having an absolute peripheral lymphocytosis of more
than 10,000/microL (>10 x 10(9)/L) at diagnosis ("leukemic";
n = 30) with those in cases having no or minimal
lymphocytosis ("nodal"; n = 19). Only cases positive
for t(11;14) were included for study. Forty-six
cases (94%) had abnormalities in addition to
t(11;14). The most frequent abnormalities involved
chromosome 13 (26 cases [53%]), followed by
chromosomes 1, 3, 7, 8, 9, 10, 12, 15, 17, and 21
(11-18 cases [22%-37%]). There was no difference in
the number of aberrations between the 2 groups.
Abnormalities of chromosomes 17, 21, and 22 were
more frequent, and breakpoints involving 8q24,
9p22-24, and 16q24 were found exclusively in
leukemic MCL. Chromosome 17 aberrations involved
were structural (breakpoints involving 17p13,
17p11.2, 17q) in leukemic MCL but were only numeric
in nodal MCL. Thus, leukemic MCL differs from nodal
MCL in their cytogenetic profiles, which may
contribute to the clinical presentation.
PMID: 11764078 [PubMed - indexed for
MEDLINE]