- Mod Pathol. 2004 Apr 9 (Listed prior to publication).
-
- TIA-1 expression in hairy cell leukemia.
Mori N, Murakami YI, Shimada S, Iwamizu-Watanabe S, Yamashita Y, Hasegawa Y, Kojima H,
Nagasawa T.
Department of Pathology of Biological Response, Nagoya University Graduate School of
Medicine, Showa-ku, Nagoya, Japan.
We measured T-cell intracellular antigen-1 (TIA-1) expression in neoplastic cells from
patients with hairy cell leukemia. Five of nine cases were positive for cytoplasmic TIA-1,
with a small, dot-like, granular expression pattern. However, neoplastic cells were
granzyme B- and perforin- negative in all cases. Other positive markers were CD20 in 9/9
cases, CD19 in 9/9 cases, DBA44 in 8/9 cases, LeuM5(CD11C) in 8/9 cases, IL-2R(CD25) in
7/9 cases, CD103 in 7/9 cases, FMC7 in 6/9 cases, and tartrate- resistant acid phosphatase
in 5/7 cases. We also analyzed TIA-1 expression in 94 B cell lymphomas, including 19
diffuse, large cell lymphomas, 19 mantle cell lymphomas, six follicular lymphomas, two
extranodal marginal zone B-cell lymphomas, 13 nodal marginal zone B-cell lymphomas, one
mediastinal large-cell lymphoma, 19 diffuse small-cell lymphomas, 14 myelomas, and one
splenic lymphoma with villous lymphocytes. All cases were negative for TIA-1 expression.
Based on these findings, TIA-1 expression in neoplastic cells of low-grade B-cell
lymphomas may be a good diagnostic marker for hairy cell leukemia. Moreover, TIA-1
reactivity in lymphomas does not necessarily indicate a T- or NK-cell derivation.Modern
Pathology advance online publication, 9 April 2004; doi:10.1038/modpathol.3800129
PMID: 15073603 [PubMed - as supplied by publisher]